Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
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Neuroactive Steroid 3a-Hydroxy-5a-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that several specific actions of alcohol (ethanol) are mediated by the neurosteroid 3a-hydroxy-5a-pregnan-20-one (3a,5a-THP; allopregnanolone). Systemic alcohol administration elevates 3a,5a-THP levels in the cerebral ...
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The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) is decreased in various brain regions of C57BL/6J mice following exposure to an acute stressor or chronic intermittent ethanol (CIE) exposure and withdrawal. It is well established that there are complex interactions between stress and ethanol drinking, with mixed literature regarding the effects of...
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The neurosteroid 3a-hyclroxy-5a-pregnan-20-one (3a,5a-THP) acts as a potent allosteric modulator and a direct activator of the GABA-chloride channel complex. This neurosteroid has also been found to protect against seizures that arise from blockade of the GABA-chloride channel complex. Because 3a,5a-THP protects against excitotoxin-induced seizure activity and because seizure activity has been ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2000
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.20-05-01982.2000